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DeCS
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Descriptor English:
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Fibrinogens, Abnormal
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Descriptor Spanish:
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Fibrinógenos Anormales
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Descriptor Portuguese:
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Fibrinogênios Anormais
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Synonyms English:
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Abnormal Fibrinogens
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Tree Number:
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D12.776.124.050.250.265
D12.776.124.125.500.265
D23.119.490.265
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Definition English:
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Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing. |
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Indexing Annotation English:
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"have a functional defect as the result of one or more amino acid substitutions in the amino acid seq of normal fibrinogen"; DF: FIBRINOGENS ABNORM
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History Note English:
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89
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Allowable Qualifiers English:
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Record Number:
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23634
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Unique Identifier:
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D015241
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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